The Systems Laboratory at the University of Michigan comprises a multidisciplinary group of researchers conducting research in systems. The lab focuses on the experimental design, implementation, and evaluation of systems software technologies, which enable the development of a wide range of emerging applications.

Enabling technologies covered by the Systems Lab include biological databases, collaborative computing, compiler and language design, embedded and real-time computing, fault-tolerant computing, file systems, host and network security systems, mobile and distributed systems, network protocols and architectures, operating systems, peer-to-peer storage systems, power-aware adaptation, security policy management, virtual machines, web databases.